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KMID : 0351819980390010073
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Kyunpook University Medical Journal
1998 Volume.39 No. 1 p.73 ~ p.79
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Efficacy and Safety of Gamma-Linolenic Acid(Epogam®) on the Treatment of Patients with Atopic Dermatitis
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Kim Do-Won
Kim Tae-Hoon
Shin Dong-Ju
Jun Jae-Bok
Chung Sang-Lip
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Abstract
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Objectives : Atopic dermatitis is a chronically relapsing skin disorder which is associated with immunological abnormalities such as excessive formation of IgI? and some abnormality in cell-mediated reaction, etc. Recent studies have shown that one of essential f<
Subjects and Methods :Twenty five patients with atopic dermatitis were treated with Epogam for 12 weeks. Clinical efficacy was assessed by three variables and clinical improvement was also measured by doctor. The first variable was to compare mean percentage of body site affected with atopic dermatitis of pre- and posmeatment. Secondly, the score of signs and symptoms of atopic dermatitis was assessed at 4, 8, and 12 weeks after taking Epogam~. Lastly, final asses:~ment on efficacy, tolerance, and overall evaluation were graded 1 (=excellent), 2 (=good), 3 (=poor) and 4 (=exacerbation) by doctor and patients respectively.
Results :For the fmal assessment, 78.6% in efficacy, 71.4% .in tolerance and overall evaluation were rated on 1(excellent) or 2(good) by doctor, and 71.4% in efficacy, 78.6% in tolerance and 71.4% in overall evaluation were rated on 1(excellent) or 2(good) by patients. Epogam~ did not have any specific adverse event during this study.
Conclusion : GLA(Epogamg) may be considered as an available drug in adjuvant treatment of atopic dermatitis.
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KEYWORD
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Gamma-linolenic acid, Atopic dermatitis
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